©  The MarlovitsLab 2011-2013


All rights reserved.

The MarlovitsLab

@ Kulcar/Marlovits

CryoEM of

Molecular Machines in Action


Design and Structural Plasticity

Function and Disease

stay tuned ....

—most recent publications

Nature Microbiology

.... Tuberculosis: Structure of the type VII secretion system from Mycobacteria elucidated for the first time.  The high flexibility of specific domains suggests an as yet unseen mode of substrate recognition.

In collaboration with the Bittner/Houben (VU Amsterdam) and Wilmanns (EMBL Hamburg) labs.

Nature communications

....  in press: Complete dissection of the regulatory elements within one of the most complex systems known (T3SS) to date,  and application of basic conceptual principles and tools from synthetic biology to refactor and build a complete functional T3SS.

In collaboration with the Voigt lab (MIT/Boston).

PLoS Pathogens

.... Biochemical, native mass spec and EM-characterization of the export apparatus of the T3SS.

In collaboration with the Robinson (Oxford), Galan (Yale) and Wagner (Tübingen) labs.

Nature methods

.... Novel methods paper for accurate atomic structure determination from density maps.

In collaboration with the Baker Lab (Seattle)

Annual Review in Microbiology

.... review “Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells”

Journal of Cell Biology

.... kinetochore paper in JCB.

In collaboration with the Westermann lab (Vienna)

Nature Structural and Molecular Biology

.... type III secretion systems in action - in vitro and in situ - first demonstration and visualization of unfolded protein transport across membranes

—welcome & farewell

.... Sandra defended her Master thesis


....  accepting applications for several experts in:

       [molecular biology and/or protein biochemistry] or [electron microscopy] (PostDoc, PhD, M.sc, TA-level)